A single-center, phase 1, open label, dosage-escalation study of creatine monohydrate in subject with amyotrophic lateral sclerosis
نویسندگان
چکیده
E-M. Ratai, N. Atassi, S. Wallace, J. Bombardier, D. Greenblatt, M. Cudkowicz, and A. Dibernardo Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, Harvard Medical School, Boston, MA, United States, Neurology, Massachusetts General Hospital, Charlestown, MA, United States, Psychiatry, Massachusetts General Hospital, Charlestown, MA, United States, Pharmacology & Experimental Therapeutics, Tufts University School of Medicine, Boston, MA, United States
منابع مشابه
A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis.
Creatine monohydrate (creatine) has potential neuroprotective properties and is a commonly used supplement in amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Minimum therapeutic and maximum tolerated dosages of creatine are not yet known, nor is it known what systemic plasma concentrations result from specific dosage regimens. The objectives of this study were to esta...
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